Po' Boys Creole & Fresh Catch is located at 900 Palmer Street which is past the Food Lion shopping center going East on Route 16 / Broadkill Road (next to the Dollar General).
 
From Route 1 South (Coastal Highway) 
Turn RIGHT at Broadkill Road.  Go approximately 2.4 miles and Po' Boys will be on your right.

From the Beaches (Lewes, Rehoboth, Dewey, Bethany)
Take Route 1 North, turn LEFT at Broadkill Road.  Go approximately 2.4 miles and Po' Boys will be on your right.